Combs Spouts Off

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Posts Tagged ‘science’

Happy birthday, transistor!

Posted by Richard on December 2, 2007

This month, the transistor turns 60. In a mere six decades, it's transformed the world, and it's showing no signs of slowing down. The Sydney Morning Herald has an excellent article by Beverly Head about the past and future of transistors:

IN DECEMBER 1947, Bells Labs scientists John Bardeen and Walter Brattain first revealed what would come to be known as the transistor.

They held the future in their hands – a device that would replace vacuum tubes in 10 years, and 60 years later has transformed electronics.

Inventions change things; great inventions change everything.

That first device was the size of a modern mobile phone. Right now, 2 million transistors could fit in the full stop at the end of this sentence. Intel has just released its new Penryn processors, which have up to 820 million transistors, and soon the standard inch-wide microprocessor will have 1 billion transistors.

At The Speculist, Stephen Gordon quoted from the above story regarding the continuing flood of innovation in computing, and then neatly captured how important and far-reaching this little electronics invention has been:

But here's the too obvious example of how transistors have changed things: I'm a guy sitting in Louisiana commenting on an article in The Sydney Morning Herald to a worldwide audience. And I'm not Walter Cronkite.

I pass it along to you, wherever you are (my last 10 visitors include Montreal, London, Cairo, and Kaoshiung, Taiwan) from a cluttered home office in Denver. And I'm not Eric Severeid.

Here's another mind-numbing factoid from the article: They're making a billion billion (1018) transistors a year now — 10 to 100 times the number of ants on Earth.

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‘Duh’ study of the week

Posted by Richard on September 4, 2007

I'm shocked, simply shocked. Cutting-edge social science research (probably federally funded) has uncovered a couple of astonishing facts. These findings further confirm the disturbing recent news that men and women are different. The groundbreaking study determined that (1) men prefer good-looking women, and (2) women are choosier than men.

Researchers questioned men and women prior to a speed-dating session about their preferences in a mate, and then compared those with their actual choices of people they'd like to meet with again. In another shocker, it seems that men and women both lie:

Men's choices did not reflect their stated preferences, the researchers concluded. Instead, men appeared to base their decisions mostly on the women's physical attractiveness.

The men also appeared to be much less choosy. Men tended to select nearly every woman above a certain minimum attractiveness threshold, Todd said.

Women's actual choices, like men's, did not reflect their stated preferences, but they made more discriminating choices, the researchers found.

The scientists said women were aware of the importance of their own attractiveness to men, and adjusted their expectations to select the more desirable guys.

I can't wait to see what valuable insights into human nature science will reveal next.
 

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The hands of a mathematician

Posted by Richard on May 25, 2007

Researchers at Britain's University of Bath are bravely exploring the subject that cost Harvard President Larry Summers his job. Fortunately for them, the link they've discovered between math ability and sex is indirect, so they may be spared the full wrath of feminists.

It seems that prenatal hormone exposure helps determine whether you're more likely to be literate or numerate, and your hands give you away:

A quick look at the lengths of children's index and ring fingers can be used to predict how well students will perform on the SAT, new research claims.

Kids with longer ring fingers compared to index fingers are likely to have higher math scores than literacy or verbal scores on the college entrance exam, while children with the reverse finger-length ratio are likely to have higher reading and writing, or verbal, scores versus math scores.

Scientists have known that different levels of the hormones testosterone and estrogen in the womb account for the different finger lengths, which are a reflection of areas of the brain that are more highly developed than others, said psychologist Mark Brosnan of the University of Bath in England, who led the study.

Exposure to testosterone in the womb is said to promote development of areas of the brain often associated with spatial and mathematical skills, he said. That hormone makes the ring finger longer.

Estrogen exposure does the same for areas of the brain associated with verbal ability and tends to lengthen the index finger relative to the ring finger.

Clearly, hormone exposure correlates with the sex of the fetus. Boy fetuses are likely to be exposed to higher levels of testosterone than girl fetuses (their little testes start making it). But both are exposed to estrogen from the mother, and the amount seems to vary quite a bit from pregnancy to pregnancy. So, boys are more likely to end up with longer ring fingers (and more spatial/math aptitude), while girls are more likely to end up with shorter ring fingers (and more verbal aptitude).

But some boys have shorter ring fingers (because they were exposed to more estrogen) and some girls have longer ring fingers (because they were exposed to lower levels of estrogen and/or higher levels of testosterone).

And some kids with short ring fingers really like math and do well at it, while some with long ring fingers do poorly for one reason or another. Aptitude is part of the puzzle, but it's not the whole story.

In any case, whenever feminists bristle at discussions of these differences, I have to wonder at their insecurity and lack of perspective. Shouldn't they celebrate the evidence that women are naturally better communicators, more literate, and better at abstract thought?

Men and women are different, all the way to the tips of their fingers. Can you digit? 

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Neptune’s inconvenient truth

Posted by Richard on May 14, 2007

We've known since at least 2005 that Mars has been warming rapidly — much more rapidly than Earth. Anthropogenic climate change skeptics like Russian astronomer Habibull Abdussamatov have argued that the warming on both planets can be explained by solar radiation changes.

Defenders of the "scientific consensus" replied that Martian warming is due to wobbles in its orbit, not solar changes, and is irrelevant to the issue of the Earth warming. Meanwhile, Jupiter and Saturn have also shown evidence of warming, and evidence of warming on Triton and Pluto has existed for years.

Now, scientists have added Neptune to the list, and with a pretty strong correlation to what's happening on Earth:

Neptune is the planet farthest from the Sun (Pluto is now considered only a dwarf planet), Neptune is the planet farthest from the Earth, and to our knowledge, there has been absolutely no industrialization out at Neptune in recent centuries. There has been no recent build-up of greenhouse gases there, no deforestation, no rapid urbanization, no increase in contrails from jet airplanes, and no increase in ozone in the low atmosphere; recent changes at Neptune could never be blamed on any human influence. Incredibly, an article has appeared in a recent issue of Geophysical Research Letters showing a stunning relationship between the solar output, Neptune's brightness, and heaven forbid, the temperature of the Earth. With its obvious implications to the greenhouse debate, we are certain you have never heard of the work and never will outside World Climate Report.

According to H.B. Hammel of Boulder's Space Science Institute and G.W. Lockwood of Lowell Observatory in Flagstaff, increased solar irradiation correlates 0.90 with Neptune's brightness increase and 0.89 with Earth's temperature rise.

So we know that solar energy output has increased for much of the 20th century (leveling off at the end of the century, just about when Earth's warming began leveling off), and we have evidence of warming on many other bodies in the solar system, and we have at least one model that closely correlates solar output with warming of two planets. But, hey, nobody cares because they've already arrived at a consensus — at least all the scientists who want to keep getting those nice grants have.

I haven't seen any information about Mercury's temperature, and I'm hesitant to bring up the evidence of warming on Venus. Some very smart people think Venus is an example of the "runaway greenhouse effect" that may be in our future if we ignore Al Gore. Never mind that the atmosphere of Venus is 96.5% carbon dioxide (the evil greenhouse gas), while Earth's CO2 level has risen from 0.028% to — gasp! — 0.036% (and that's a tenth of what it was a few hundred million years ago).

Gosh, practically every sizable body in the solar system seems to be getting warmer. I only have one more question, but I'm reluctant to ask it because this isn't that kind of blog.

Oh, what the heck…

Is Uranus getting hot?

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“Climate of Fear”

Posted by Richard on May 2, 2007

Don't miss Glenn Beck's second "Exposed" special tonight on the Headline News Network. It airs at 7 PM, 9 PM, and midnight Eastern Time. The special report, entitled "Climate of Fear,"  examines the global warming debate, looking at causes, solutions, and in particular, at the growing efforts to silence critics and crush dissent:

"If you believe the mainstream media hype, you'd think that every time you drive your SUV, the Earth's temperature rises six degrees," Beck said. "The reality is that many respected climatologists have questions about both the problem and the solution. We should understand both positions more fully before committing to any solutions that could do more harm than good, both to our environment and our economy."

During this special report, Glenn Beck questions the accuracy of Al Gore's claims in the Oscar-winning documentary An Inconvenient Truth of 20-foot sea level rises and the disastrous effects of increased carbon dioxide levels. The program examines the criticism some esteemed scientists, climatologists and academics have faced for even raising questions about the "scientific consensus."

The special report also offers a look at the history of what Beck sees as the media hype involving the climate, recalling the "global cooling" scare of the mid-1970s and the transition to the latest round of warnings about global warming.

Finally, Glenn Beck considers solutions and examines the Kyoto Treaty, a current guiding principle for the nations of the world to fix the problem of global warming. Beck himself offers his own ideas suggesting innovation – not government regulation – is the answer to solving this problem.

I thought that Beck's first special report, "Exposed: The Extremist Agenda," was an excellent look at Islamofascists' goals presented in their own words. If this one is of similar quality, it will be well worth watching. It's likely to be considerably lighter and more entertaining. Beck can be pretty funny.

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The health hazards of burning ethanol

Posted by Richard on April 20, 2007

It seems that there's another downside to the latest fad for saving the planet, ethanol-powered vehicles:

Ethanol advocates say that it's a clean-burning fuel that is friendly to the environment. But a study by Stanford University atmospheric scientist Mark Z. Jacobson found that if all U.S. vehicles ran on ethanol, the number of respiratory-related deaths and hospitalizations would likely increase.

Jacobson's work, reported in Environmental Science & Technology, involved the simulation of atmospheric conditions throughout the United States in 2020, with a special focus on Los Angeles. According to Jacobson:

  • Research found that E85 vehicles reduce atmospheric levels of two carcinogens, benzene and butadiene, but increase two others — formaldehyde and acetaldehyde.
  • As a result, cancer rates for E85 are likely to be similar to those for gasoline; However, E85 significantly increased ozone, a prime ingredient of smog.
  • The simulations revealed that E85 would increase ozone-related mortalities by about 4 percent in the United States and 9 percent in Los Angeles.
  • In addition, the deleterious health effects of E85 will be the same, whether the ethanol is made from corn, switchgrass or other plant products.

''Today, there is a lot of investment in ethanol,'' Jacobson said.  ''But we found that using E85 will cause at least as much health damage as gasoline, which already causes about 10,000 U.S. premature deaths annually from ozone and particulate matter."

 More smog and respiratory illness aren't the only problems with ethanol fuel. As subsidies and mandates divert more and more corn into ethanol production, and more and more acres into corn, we'll see much higher food prices, with more hunger and famine in some parts of the world. And don't forget that planting more and more acres of corn leads to cutting — or not replanting — more and more acres of trees.

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Math challenged

Posted by Richard on April 9, 2007

The Large Hadron Collider is a $4 billion proton accelerator project at the Cern complex in Switzerland. It’s intended to mimic the conditions of the Big Bang. Recently, scientists there created a big bang all right, thanks to some embarrassing mistakes in simple math:

The mistakes led to an explosion deep in the tunnel at the Cern particle accelerator complex near Geneva in Switzerland. It lifted a 20-ton magnet off its mountings, filling a tunnel with helium gas and forcing an evacuation.

It means that 24 magnets located all around the 17-mile circular accelerator must now be stripped down and repaired or upgraded. The failure is a huge embarrassment for Fermilab, the American national physics laboratory that built the magnets and the anchor system that secured them to the machine.

It appears Fermilab made elementary mistakes in the design of the magnets and their anchors that made them insecure once the system was operational.

That’s what they get for letting Americans make critical mathematical calculations. Don’t they realize that, when it comes to math, Americans are typically cocky and dumb?ย  ๐Ÿ˜‰

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Health news updates

Posted by Richard on March 6, 2007

Back in September, I warned you to start taking vitamin D supplements as the days grew short. I hope you did, and I hope it helped you avoid the flu this winter. The February issue of Life Extension Magazine (yes, I’m a bit behind in my reading) has an article that goes into much greater depth regarding the connection between seasonally low levels of vitamin D and high rates of influenza. It includes information about how vitamin D helps protect you:

In the past few years, several independent researchers have shown that vitamin D significantly enhances the genetic expression of antimicrobial peptides in human monocytes (precursors to macrophages), neutrophils, and other immune system cells.15,1617-19

For Dr. Cannell, these various clues led to one inescapable conclusion: vitamin D—which is produced when the skin is exposed to summer sunlight, and which, conversely, declines in winter—plays a critical role in our vulnerability to influenza infection. In fact, vitamin D must surely be Hope-Simpson’s mysterious “seasonal stimulus.” Dr. Cannell consulted a number of leading vitamin D researchers, all of whom agreed with his conclusions. They include researchers from such venerable institutions as the National Institutes of Health and the Harvard School of Public Health. One of these scientists, Dr. Michael F. Holick, has been studying vitamin D for three decades.1,7,20

In an interview with Life Extension, Dr. Holick alluded to the special relationship between vitamin D and the body’s primary immune system defenders, the macrophages. “What intrigues me the most,” Dr. Holick noted, “is that we’ve always known that macrophages activate vitamin D.” The form of vitamin D generated through the skin’s interaction with ultraviolet B radiation (from sunshine or artificial sources) is a pre-hormone. It must be converted in the body to its active hormone form, called 1,25-dihydroxyvitamin D3. An intermediary form, known as 25-hydroxyvitamin D, is the major circulating form of vitamin D, and is measured to determine vitamin D status.20

Most of this activation of vitamin D occurs in the liver and kidneys. However, the fact that macrophages facilitate the conversion of circulating vitamin D to its active form,20 and that activated vitamin D in turn regulates the activity of macrophages, suggests an important relationship between the two. These antimicrobial proteins help to destroy invading infectious microbes. With their broad-spectrum activity, they are capable of killing everything from bacteria to viruses. They have been shown to be an important part of the respiratory tract’s defense against invaders, and likewise show promise in fighting the influenza virus.

Life Extension Foundation has also taken aim at the shoddy supplement study I wrote about last week, issuing a consumer alert entitled "Another Flawed Attack against Antioxidants." Among other issues, LEF looked at the ridiculously wide range of nutrient dosages in the studies:

The JAMA review that attacked the value of antioxidants included vitamins A, C, E, and selenium and evaluated these very basic nutrients in a very wide & inconsistent dosage range:

Supplement

Dose range

Vitamin A (synthetic)

1,333200,000*** IU

Alpha Tocopherol (synthetic)

105,000 IU

Vitamin C (synthetic)

60 – 2,000 mg

Selenium (natural)

20 – 200 mcg

As an example of the strange decisions made by the JAMA authors as to which studies to exclude or include in their analysis, they selected a single dose study*** of patients using 200,000 IU of vitamin A, who were subsequently followed for 3 months.8

LEF also found that the authors misrepresented some of the included studies, attributing deaths that didn’t happen, and seem to have intentionally omitted a long list of studies that demonstrated positive benefits from antioxidants from their cherry-picked (68 out of 815) sample. LEF characterized the JAMA study as an "irrational and highly biased attack," and quoted several other respected scientists who dismissed this study as deeply flawed.
 

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Lancet study looks more and more bogus

Posted by Richard on March 5, 2007

Remember the Johns Hopkins study published in Lancet last October? The researchers claimed that our invasion of Iraq had led to more than 650,000 "excess" deaths (one in 40 Iraqis) since March 2003. I thought the number was absurd and suspected fraud for political purposes. Quite a few bloggers looked at the study and found it wanting, as did the Prez. But defenders argued that we critics simply lacked the in-depth knowledge of statistics needed to understand the sophisticated methodology employed.

Well, according to The Times of London, a number of people who do have an in-depth knowledge of statistics don’t think much of the study, either (emphasis added):

The controversy has deepened rather than evaporated. Several academics have tried to find out how the Lancet study was conducted; none regards their queries as having been addressed satisfactorily. Researchers contacted by The Times talk of unreturned e-mails or phone calls, or of being sent information that raises fresh doubts.

“The authors ignore contrary evidence, cherry-pick and manipulate supporting evidence and evade inconvenient questions,” contends Professor Spagat, who believes the paper was poorly reviewed. “They published a sampling methodology that can overestimate deaths by a wide margin but respond to criticism by claiming that they did not actually follow the procedures that they stated.” The paper had “no scientific standing”. Did he rule out the possibility of fraud? “No.”

Some of the information about how the survey was conducted was new to me. Burnham, Roberts, et al — the Johns Hopkins "researchers" — never set foot in Iraq, did no research themselves, and apparently can’t actually vouch for how the survey was conducted:

They drafted in Professor Riyadh Lafta, at Al Mustansiriya University in Baghdad, as a co-author of the Lancet paper. Professor Lafta supervised eight doctors in 47 different towns across the country. In each town, says the paper, a main street was randomly selected, and a residential street crossing that main street was picked at random.

The doctors knocked on doors and asked residents how many people in that household had died. … Out of 1,849 households contacted, only 15 refused to participate.

A claimed participation rate of over 99%? Gee, there’s nothing suspicious about that!

One of the critics of the study is a former associate, Dr. Richard Garfield. Of course, his complaint seems to be that there was underreporting:

Together with Professor Hans Rosling and Dr Johan Von Schreeb at the Karolinska Institute in Stockholm, Dr Garfield wrote to The Lancet to insist there must be a “substantial reporting error” because Burnham et al suggest that child deaths had dropped by two thirds since the invasion. The idea that war prevents children dying, Dr Garfield implies, points to something amiss.

Professor Rosling was one of several academics who complained about stonewalling:

Professor Rosling says that, despite e-mails, “the authors haven’t provided us with the information needed to validate what they did”. He would like to see a live blog set up for the authors and their critics so that the matter can be clarified.

Another critic is Dr Madelyn Hsaio-Rei Hicks, of the Institute of Psychiatry in London, who specialises in surveying communities in conflict. In her letter to The Lancet, she pointed out that it was unfeasible for the Iraqi interviewing team to have covered 40 households in a day, as claimed. She wrote: “Assuming continuous interviewing for ten hours despite 55C heat, this allows 15 minutes per interview, including walking between households, obtaining informed consent and death certificates.”

I’d say that Hicks has totally destroyed the credibility of this study with one simple little calculation involving only the most basic math. No advanced statistics knowledge required.

Does she think the interviews were done at all? Dr Hicks responds: “I’m sure some interviews have been done but until they can prove it I don’t see how they could have done the study in the way they describe.”

Professor Burnham says the doctors worked in pairs and that interviews “took about 20 minutes”. The journal Nature, however, alleged last week that one of the Iraqi interviewers contradicts this. Dr Hicks says: : “I have started to suspect that they [the American researchers] don’t actually know what the interviewing team did. The fact that they can’t rattle off basic information suggests they either don’t know or they don’t care.”  

Burnham told The Times he had "“full confidence in Professor Lafta and full faith in his interviewers.” Well, that settles it. No need to wonder about how those interviews were done. No need to validate the data or clarify the methodology.

Dr. Burnham has assured us that he has "full faith." That’s how they’re doing science at Johns Hopkins these days.
 

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Another shoddy supplement study

Posted by Richard on March 1, 2007

Last March, I commented on several shoddy studies of nutritional supplements, singling out a calcium / vitamin D study that Life Extension Foundation’s Bill Faloon described as perhaps "one of the most poorly designed studies in the history of modern medicine." Well, the February 28 issue of the Journal of the American Medical Association (JAMA) reports a "meta-analysis" of antioxidants that has to rank pretty high on the list of bogus studies. It purports to demonstrate that there is no health benefit associated with vitamins A, C, and E, beta carotene, and selenium, and that A and E may "significantly increase mortality."

The Linus Pauling Institute at Oregon State University was quick to criticize the study. Its director, Balz Frei, said the meta-analysis had multiple serious flaws:

“This is a flawed analysis of flawed data, and it does little to help us understand the real health effects of antioxidants, whether beneficial or otherwise,” Frei said.

The “meta-analysis” published in JAMA, which is a statistical analysis of previously published data, looked at 815 antioxidant trials but included only 68 of them in its analysis, Frei said. And two of the studies excluded – which were published in the Journal of the National Cancer Institute and the prominent British medical journal Lancet – found substantial benefits and reduced mortality from intake of antioxidant supplements.

It’s not as if the researchers conducting this meta-analysis carefully selected the best, most unambiguous 68 trials out of the 815 they considered. Instead, they picked mainly various clinical trials of subjects with existing health problems. Furthermore, these sick subjects were getting a variety of pharmaceutical drugs, other nutrients, or other treatments, thus making any conclusions about the specific nutrients being "meta-analyzed" ambiguous and suspect.

The Council for Responsible Nutrition argued that this study represents a misuse of meta-analysis (emphasis added):

"Healthy consumers can feel confident in continuing to take antioxidants for the benefits they provide. This meta-analysis does nothing to change those facts," said CRN’s Andrew Shao, Ph.D., vice president, scientific and regulatory affairs. "While meta-analyses can be useful when the included studies are very similar in design and study population, this meta-analysis combined studies that differ vastly from each other in a number of important ways that compromise the results."

For example, the meta-analysis included clinical trials that varied widely in terms of dosage, duration, study population and nutrients tested — such as data from a one-day study with a vitamin A dose of 200,000 IU mixed with data from other studies lasting years.

200,000 IU of Vitamin A?? According to the NIH Office of Dietary Supplements, the "Tolerable Upper Intake Level" of retinol (vitamin A) is 10,000 IU.

"Moreover, the overwhelming majority of the clinical trials included in the meta-analysis tested for secondary prevention, looking at how a nutrient works in those who already are diseased, instead of primary prevention studies in healthy populations.

"Combining secondary prevention and primary prevention trials and then making conclusions for the entire population is an unsound scientific approach," said Dr. Shao. "Additionally, many of the treatment trials had limitations, including the expectation that a simple antioxidant vitamin could be expected to overturn serious illness, such as cancer or heart disease. These trials likely statistically skewed the results."

When it comes to studying nutrients, herbs, and the like, the methodology favored by many mainstream medical researchers seems to be something like this: Give a bunch of people who have, say, heart disease some supplement. If lots of them die, announce that taking the supplement can kill you. If lots of them get well, caution the public that further study is needed. Meanwhile, try to come up with a chemical analogue of the supplement that works about the same, but can be patented and sold as a prescription drug.
 

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Cool meteor over Denver

Posted by Richard on January 4, 2007

SkyFOX, the KDVR-31 traffic helicopter, captured some pretty cool video of an impressive meteor breaking up in the Denver sky this morning just before dawn. Check it out. Try to ignore the less than brilliant commentary.

Meteor breaking up over Denver

UPDATE: It wasn’t a meteor, it was "space junk" — part of a Russian SL-4 rocket that re-entered the atmosphere.
 

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British lord demands senators “honour the Constitution”

Posted by Richard on December 20, 2006

It’s a sad indicator of the sorry state of American politics in general and the U.S. Senate in particular that a British lord has to remind American senators that the U.S. Constitution protects freedom of speech, and that attempts by senators to silence ExxonMobil, accompanied by thinly-veiled threats, violate their oath of office. Bravo, Lord Monckton!

WASHINGTON, Dec. 18 /PRNewswire/ — Lord Monckton, Viscount of Brenchley, has sent an open letter to Senators Rockefeller (D-WV) and Snowe (R-Maine) in response to their recent open letter telling the CEO of ExxonMobil to cease funding climate-skeptic scientists.
(http://ff.org/centers/csspp/pdf/20061212_monckton.pdf)
.

The entire Monckton letter (link above is to PDF) is well worth reading. It begins (emphasis added):

The US Constitution guarantees the right of free speech. It is inappropriate for elected Senators such as yourselves to suggest that any person should refrain from exercising that right, as you have done in your letter of October 27 to the CEO of ExxonMobil. …

You defy every tenet of democracy when you invite ExxonMobil to deny itself the right to provide information to “senior elected and appointed government officials” who disagree with your opinion. You are elected officials yourselves. If you do not believe in the right of persons within the United States to exercise their fundamental right under the world’s greatest Constitution to petition their elected representatives for the redress of their grievances, then you have no place on Capitol Hill. You must go.

Your letter says climate change is “a matter of urgency for all mankind”. It is not. The UN’s 2001 report estimates our greenhouse effect compared with 1750 AD as 2.43 watts per square metre. Its new report will cut that figure to 1.6 watts, little more than 1 per cent of the 150-watt natural greenhouse effect.

The UN will also reduce its high-end estimate of sea-level rise to 2100 from 3 feet to just 17 inches. Morner (2004), a lifelong student of sea level changes, says: “There is a total absence of any recent ‘acceleration in sea level rise’ as often claimed by IPCC and related groups. … our best estimate of possible future sea-level changes is +10 +/- 10cm in a century, or, maybe, even +5 +/- 15cm.” That is a maximum of 8 inches in 100 years. See also Morner (1995); INQUA (2000).

All other imagined consequences of climatic warming are more likely to be beneficial than harmful.

The seven-page letter, which includes references for the studies cited, goes on to provide an excellent, readable summary of the state of knowledge — and misinformation — about climate change, and to deliver a fine verbal thrashing to Senators Rockefeller and Snowe. It closes with (emphasis added):

Finally, you may wonder why it is that a member of the Upper House of the United Kingdom legislature, wholly unconnected with and unpaid by the corporation that is the victim of your lamentable letter, should take the unusual step of calling upon you as members of the Upper House of the United States legislature either to withdraw what you have written or resign your sinecures.
 
I challenge you to withdraw or resign because your letter is the latest in what appears to be an internationally-coordinated series of maladroit and malevolent attempts to silence the voices of scientists and others who have sound grounds, rooted firmly in the peer-reviewed scientific literature, to question what you would have us believe is the unanimous agreement of scientists worldwide that global warming will lead to what you excitedly but unjustifiably call “disastrous” and “calamitous” consequences. Let me give just two examples from this side of the Atlantic:

The Institute for Public Policy Research, a Leftist pressure-group, has stated that public bodies should act henceforth as though there is no debate among scientists and should assume that “disastrous” and “calamitous” climate change will be a fact.

The British “Foreign Secretary”, one Beckett, responded to a recent newspaper article by me that questioned the science behind the soi-disant “consensus” on climate change by demanding – during an otherwise paralyzing speech on terrorism – that the news media should treat climate sceptics as though they were spokesmen for Islamic terrorism and should deny them column inches or air time. Al Gore, who was Vice-President when the Senate declared 97-0 that it would not ratify any treaty that did not bind fast-growing, heavily-polluting nations such as China, India, Indonesia and Brazil because without them no action by the West would make any difference, wrote a reply to my article saying that I should not be discussing these matters in the Press. He said I should rely on peer-reviewed research in journals such as Science, Nature and Geophysical Research Letters. Within 12 hours, I had published a 24-page refutation of his scientifically-inaccurate article, citing more than 60 references in learned journals. Twenty-five of the citations were from the three journals he mentioned.

You will rightly deduce from Beckett’s sinister remark that after a decade of Socialist government freedom of speech does not figure in our constitution. But let me quote the First Amendment to yours:

“Congress shall make no law respecting an establishment of religion or prohibiting the free exercise thereof, or abridging the freedom of speech or of the Press, or the right of the people peaceably to assemble and to petition the Government for a redress of grievances.”

I call upon the pair of you to live by those great words, or to leave. Yours truly,

MONCKTON OF BRENCHLEY

Outstanding. I wish we had some Moncktons in the United States Senate.
 

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Drink up, fatsos!

Posted by Richard on November 6, 2006

So, let’s say you’re one of the 65% of Americans who are obese. And let’s say you’re worried about the health consequences of those extra pounds — including double the risk of heart disease, high blood pressure, and arthritis, and triple the risk of diabetes. So, what are you going to do about it?

Well, you could walk more, join a gym, and start working out. You could forego that plate of ribs and order a nice salad with low-fat dressing.

Or you could just order a nice bottle of Shiraz to go with those ribs:

Good news for gluttons and anyone else who gets old: Scientists are looking for the antidote for age and disease in a glass of red wine.

Harvard Medical School and National Institute of Aging researchers have found that a natural susbtance found in red wine, known as resveratrol, countered the ravenous ways of mice fed a high-calorie diet and even prolonged their lives.

“Resveratrol can excuse most of the negative effects of being obese in the mice,” said Harvard Medical School professor David Sinclair, one of the study’s authors.

The study compared three groups of mice. The first ate a standard (30% fat) diet, the second ate a high-fat (60%) diet, and the third ate the high-fat diet supplemented with resveratrol.

The third group got just as fat as the second, but suffered none of the ill effects. Their hearts, livers, and other organs remained normal (in fact, somewhat healthier than the standard-diet group’s). Their blood sugar levels and insulin sensitivity mirrored the lean group’s. And they lived longer:

… After 114 weeks, 58 percent of the normally fed mice and the resveratrol group were still alive, compared with only 42 percent of the untreated, high-calorie-intake mice. Sinclair reports that resveratrol reduced the risk of death from a high-calorie diet by 31 percent, leading to an increase in life span of 15 percent thus far. More accurate numbers will be available when all the mice pass away. "We are around five months from having final numbers," Sinclair notes, "but there is no question that we are seeing increased longevity." The researchers also note that the resveratrol-treated mice not only live longer than their untreated counterparts, but have more active lives, too–their motor skills have actually improved as they have aged.

Of course, there are caveats. To get as much resveratrol as the mice, you’d have to drink a hundred or more glasses of wine (depending on which news report you believe) — clearly, supplement capsules would be a more practical choice. And everybody from the science reporters to the researchers is mouthing the usual warnings that you always hear regarding nutritional supplements:

While resveratrol supplements are available at many health food stores, experts caution that no one knows whether the compound will work the same way for humans and, perhaps more important, whether high doses of resveratrol are harmful in the long run.

It’s worth noting, though, that researcher David Sinclair founded a company to develop resveratrol-related drugs (in which he and Harvard Medical School have a financial interest).

And Sinclair has been taking resveratrol supplements himself for three years already.
 

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Grammar saves lives

Posted by Richard on October 19, 2006

If you’re like many people, you’ve wondered why your English teachers made you learn all those grammar rules — you’ve forgotten most of them, and yet you get along just fine.

Of course, if you’re significantly younger than me, your English teachers probably never made you learn them in the first place, believing that any emphasis on tedious subjects like grammar, punctuation, and spelling would merely stifle your creativity and potentially damage your self-esteem.

Well, it turns out that knowing the basics of grammar can help you conquer drug-resistant microbes and save lives:

Studying a potent type of bacteria-fighters found in nature, called antimicrobial peptides, biologists found that they seemed to follow rules of order and placement that are similar to simple grammar laws. Using those new grammar-like rules for how these antimicrobial peptides work, scientists created 40 new artificial bacteria-fighters.

Nearly half of those new germ-fighters vanquished a variety of bacteria and two of them beat anthrax, according to a paper in Thursday’s journal Nature.

This potentially creates not just a new type of weapon against hard-to-fight germs, but a way to keep churning out new and different microbe-attackers so that when bacteria evolve new defenses against one drug, doctors won’t be stymied.

Using grammar as their guide, scientists could easily produce tens of thousands of new bacteria-fighters and test them for use as future drugs, said study lead author Gregory Stephanopoulos, a chemical engineering professor at the Massachusetts Institute of Technology.

Now aren’t you glad that at least Dr. Stephanopoulos and his pals were paying attention in English class?
 

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Hops for health

Posted by Richard on June 12, 2006

As you contemplate whether to join us for next Saturday’s "Get Dr. Cutter Drunk" Mini Blogger Bash, be sure to factor in the possible health ramifications of attending. For instance, if you’re a male, you might want to consider that drinking lots of good, hoppy beer (like India Pale Ale or Pilsner) can protect you from both prostate enlargement and prostate cancer, according to Oregon State University researchers:

The research, published in a recent issue of Cancer Letters, shows that xanthohumol, a compound found in hops, inhibits NF-kappaB protein in cells along the surface of the prostate gland, said Emily Ho, assistant professor of nutrition and exercise sciences in OSU’s College of Health and Human Sciences and a researcher with OSU’s Linus Pauling Institute. The protein acts like a signal switch that turns on a variety of animal and human malignancies, including prostate cancer.

"We’ve shown that the addition of xanthohumol in a cell culture blocks the signal of NF-KappaB protein and works to slow down the growth of benign prostatic hyperplasia and malignant prostate cancer cells," Ho said.

Xanthohumol, which belongs to a group of plant compounds called flavonoids, can also trigger programmed cell death, which plays a role in cancer prevention, as uncontrolled cell reproduction is a cause of cancer.

But don’t rush out to stock the refrigerator. Xanthohumol, is present in such small amounts that a person would have to drink more than 17 beers to consume the same amount found effective in the study, Ho said.

I don’t get Ho’s cautionary note. Beers vary by more than an order of magnitude in how much hops — and therefore xanthohumol — they contain, so I’m not sure how meaningful the number 17 is. If that’s 17 Buds or Millers, then you could replace them with 3 or 4 American IPAs — or maybe 1 or 2 double IPAs. Besides, what’s the problem with drinking more than 17 beers? I mean, Ho didn’t specify a time constraint. ๐Ÿ™‚

You say you’re not into beer? Well, fear not — according to researchers in Seattle (what is it about scientists in the Pacific Northwest and alcohol research?), you can protect your prostate with some red wine instead:

Drinking a glass of red wine a day may cut a man’s risk of prostate cancer in half, and the protective effect appears to be strongest against the most aggressive forms of the disease, according to a new study led by investigators at Fred Hutchinson Cancer Research Center.

"We found that men who consumed four or more glasses of red wine per week reduced their risk of prostate cancer by 50 percent," Stanford said. "Among men who consumed four or more 4-ounce glasses of red wine per week, we saw about a 60 percent lower incidence of the more aggressive types of prostate cancer," said Stanford, senior author of the study. "The more clinically aggressive prostate cancer is where the strongest reduction in risk was observed."

As for those of you of the female persuasion, you can benefit from the xanthohumol in beer and the resveratrol in red wine, too:

In more news from the Experimental Biology 2004 meeting, held April 17 to 21 in Washington, DC, S. Pinheiro-Silva, I. Azevedo, and C. Calhau from the Universidade do Porto, in Portugal have shown that the phenolic phytochemicals epigallocatechin gallate (EGCG), xanthohumol, and resveratrol slow breast cancer growth in human cell cultures. The compounds are found in tea, beer, and wine respectively, a fact that appears to contradict the results of previous research that established an association between alcohol consumption and an increased risk of breast cancer in women. …

It was discovered that all of the compounds possessed an inhibitory effect on breast cancer cell growth, with xanthohumol eliciting an antiproliferative effect more rapidly and at a lower concentration than the other compounds.

Of course, alcohol does have negative health consequences, too. So you may want to order some of this. Then, drink up — to your health!

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